Simeprevir
Cat. No.：YN370244
CAS No. ：923604-59-5
| 产品名称: | Simeprevir |
| CAS No.: | 923604-59-5 |
| Chemical Name: | (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a( |
| Synonyms: | 西咪匹韦; TMC435 |
| 分子量: | 749.94 |
| 分子式: | C₃₈H₄₇N₅O₇S₂ |
| SMILES: | COC1=C(C)C2=C(C(O[C@H]3C[C@@H](C(N(C)CCCC/C=C\[C@H](C4)[C@]4(C(NS(=O)(C5CC5)=O)=O)N6)=O)[C@H](C6=O)C3)=CC(C7=NC(C(C)C)=CS7)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Simeprevir (TMC435) 是一种口服有效的HCV NS3/4A蛋白酶抑制剂，Ki值为 0.36 nM，并抑制HCV 复制，EC50值为 7.8 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lin, T., et al.: Antimicrobial Agents and chemotherapy, 53 (4), 1377 (2009)
J. Hepatology, 55 (2), 1377 (2011)
