Grazoprevir
Cat. No.：YN372281
CAS No. ：1350514-68-9
| 产品名称: | Grazoprevir |
| CAS No.: | 1350514-68-9 |
| Chemical Name: | (1R,2S)-N-[[[(1R,2R)-2-[5-(3-hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-cyclopropanecarboxamide, cyclic (1→2)-ether |
| Synonyms: | MK-5172 |
| 分子量: | 766.90 |
| 分子式: | C₃₈H₅₀N₆O₉S |
| SMILES: | COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Grazoprevir (MK-5172) 是选择性的丙型肝炎病毒 NS3/4a蛋白酶抑制剂，作用于 gt1b，gt1a，gt2a，gt2b 和 gt3a的Ki分别为 0.01 nM，0.01 nM，0.08 nM，0.15 nM 和 0.90 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Summa, V., Ludmerer, S.W., McCauley, J.A., et al.MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variantsAntimicrob. Agents Chemother.56(8),4161-4167(2012)
Vallet-Pichard, A., and Pol, S.Grazoprevir/elbasvir combination therapy for HCV infectionTherap. Adv. Gastroenterol.10(1),155-167(2017)
