NKL 22
Cat. No.：YN290008
CAS No. ：537034-15-4
| 产品名称: | NKL 22 |
| CAS No.: | 537034-15-4 |
| Chemical Name: | N1-(2-aminophenyl)-N7-phenyl-heptanediamide |
| Synonyms: | PAOA,Histone Deacetylase Inhibitor IV |
| 分子量: | 325.40 |
| 分子式: | C₁₉H₂₃N₃O₂ |
| SMILES: | O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NKL 22 (化合物 4b) 是一种有效的选择性组蛋白脱乙酰基酶 (HDAC) 抑制剂，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。NKL 22 对 HDAC2/4/5/7/8 (IC50≥1.59 μM) 具有选择性。NKL 22 改善了亨廷顿氏病转基因小鼠的疾病表型和转录异常。 |
| IC50和靶点: | [{name:"HDAC1:0.199 μM (IC50)"},{name: "HDAC2:1.59 μM (IC50)"},{name: "HDAC3:0.069 μM (IC50)"},{name: "HDAC8:5 μM (IC50)"}] |
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Jia, H., Pallos, J., Jacques, V., et al.Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's diseaseNeurobiol. Dis.46(2),351-361(2012)
Mai, A., Perrone, A., Nebbioso, A., et al.Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activitiesBioorg. Med. Chem. Lett.18(8),2530-2535(2008)
Jia, H., Kast, R.J., Steffan, J.S., et al.Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitin-proteasomal and autophagy systemsHum. Mol. Genet.21(24),5280-5293(2012)
