Splitomicin
Cat. No.：YN290012
CAS No. ：5690-03-9
| 产品名称: | Splitomicin |
| CAS No.: | 5690-03-9 |
| Chemical Name: | 1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one |
| Synonyms: | Splitomycin |
| 分子量: | 198.22 |
| 分子式: | C₁₃H₁₀O₂ |
| SMILES: | O=C1CCC2=C3C=CC=CC3=CC=C2O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Splitomicin (Splitomycin) 是一种选择性的Sir2p抑制剂。Splitomicin 抑制 Sir2 蛋白的 NAD+依赖性 HDAC 活性。Splitomicin 抑制酵母提取物中 HDAC，IC50为 60 μM。 |
| IC50和靶点: | [{name:"Sir2p:60 μM (IC50)"}] |
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Bedalov, A., Gatbonton, T., Irvine, W.P., et al.Identification of a small molecule inhibitor of Sir2pProc. Natl. Acad. Sci. USA98(26),15113-15118(2001)
Hirao, M., Posakony, J., Nelson, M., et al.Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeastJ. Biol. Chem.278(52),52773-52782(2003)
Posakony, J., Hirao, M., Stevens, S., et al.Inhibitors of Sir2: Evaluation of splitomicin analoguesJ. Med. Chem.47,2635-2644(2004)
Biacsi, R., Kumari, D., and Usdin, K.SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndromePLoS Genet.4(3),(2008)
Liu, F.C., Liao, C.H., Chang, Y.W., et al.Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ releaseThromb. Res.124,199-207(2009)
Kang, M.R., Lee, S.W., Um, E., et al.Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: Implication in the retinoic acid-induced neuronal differentiation of P19 cellsNucleic Acids Res.38(3),822-831(2010)
