MPI_5a
Cat. No.：YN290140
CAS No. ：1259296-46-2
| 产品名称: | MPI_5a |
| CAS No.: | 1259296-46-2 |
| Chemical Name: | 1,2,3,4-tetrahydro-N-hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-6-isoquinolinecarboxamide |
| Synonyms: | MPI 5a,MPI5a |
| 分子量: | 299.32 |
| 分子式: | C₁₆H₁₇N₃O₃ |
| SMILES: | O=C(C1=CC2=C(CN(C(C3=CC=CN3C)=O)CC2)C=C1)NO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MPI_5a 是一种高效、选择性的HDAC6抑制剂 (IC50=36 nM)。MPI_5a 对其他 HDAC 酶的抑制作用很弱。MPI_5a 抑制细胞内酰基微管蛋白的积累的 IC50值为 210 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yang, P.H., Zhang, L., Zhang, Y.J., et al.HDAC6: Physiological function and its selective inhibitors for cancer treatmentDrug Discov.Ther.7(6),233-242(2013)
Blackburn, C., Barrett, C., Chin, J., et al.Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoformJ. Med. Chem.56(18),7201-7211(2013)
