CHDI-390576
Cat. No.：YN290163
CAS No. ：1629729-98-1
| 产品名称: | CHDI-390576 |
| CAS No.: | 1629729-98-1 |
| Chemical Name: | |
| Synonyms: | CHDI390576 |
| 分子量: | 391.32 |
| 分子式: | C₁₉H₁₃F₄N₃O₂ |
| SMILES: | O=C(NO)C(C1=C(F)C=CC=C1)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHDI-390576，一种有效的细胞渗透性和中枢神经系统渗透性的 IIa 类组织乙酰酶(HDAC)抑制剂，IIa 类 HDAC 4、HDAC 5、HDAC 7、HDAC 9 的IC50值分别为 54 nM、60 nM、31 nM、50 nM，选择性高于 I 类 HDAC (1, 2, 3) 500 倍，高于 HDAC8 和 IIb 类 HDAC6 亚型约 150 倍。 |
| IC50和靶点: | [{name:"HDAC4:54 nM (IC50)"},{name: "HDAC5:60 nM (IC50)"},{name: "HDAC7:31 nM (IC50)"},{name: "hHDAC9:50 nM (IC50)"},{name: "HDAC1:39.7 μM (IC50)"},{name: "HDAC3:25.8 μM (IC50)"},{name: "HDAC8:9.1 μM (IC50)"},{name: "hHDAC6:6.2 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
