SS-208
Cat. No.：YN290211
CAS No. ：2245942-72-5
| 产品名称: | SS-208 |
| CAS No.: | 2245942-72-5 |
| Chemical Name: | 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-3-isoxazolecarboxamide |
| Synonyms: | SS208 |
| 分子量: | 344.15 |
| 分子式: | C₁₃H₁₁Cl₂N₃O₄ |
| SMILES: | O=C(C1=NOC(CCNC(C2=CC=C(Cl)C(Cl)=C2)=O)=C1)NO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SS-208 是一个选择性的HDAC6抑制剂，IC50值为 12 nM。SS-208 具有有效的抗黑色素瘤活性。 |
| IC50和靶点: | [{name:"HDAC6:12 nM (IC50)"},{name: "HDAC8:1.23 μM (IC50)"},{name: "HDAC1:1.39 μM (IC50)"},{name: "HDAC11:5.12 μM (IC50)"},{name: "HDAC5:6.91 μM (IC50)"},{name: "HDAC7:8.34 μM (IC50)"}] |
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Shen, S., Hadley, M., Ustinova, K., et al.Discovery of a new isoxazole-3-hydroxamate-based histone deacetylase 6 inhibitor SS-208 with antitumor activity in syngeneic melanoma mouse modelsJ. Med. Chem.62(18),8557-8577(2019)
