PTACH
Cat. No.：YN290231
| 产品名称: | PTACH |
| CAS No.: | 848354-66-5 |
| Chemical Name: | S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester, 2-methyl-propanethioic acid |
| Synonyms: | NCH-51 |
| 分子量: | 390.56 |
| 分子式: | C₂₀H₂₆N₂O₂S₂ |
| SMILES: | CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PTACH (NCH-51) 是一种新型HDAC抑制剂, PTACH有效抑制各种人癌细胞生长, EC50值为1至10 μM。 |
| IC50和靶点: | [{name:"HDAC1:48 nM (IC50)"},{name: "HDAC4:32 nM (IC50)"},{name: "HDAC6:41 nM (IC50)'}, 'HIV-1'] |
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| Solvent & Solubility: |
Victoriano, A.F.B., Imai, K., Togami, H., et al.Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expressionFEBS Lett.585(7),1103-1111(2011)
Suzuki, T., Kouketsu, A., Itoh, Y., et al.Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrateJ. Med. Chem.49(16),4809-4812(2006)
Suzuki, T., Nagano, Y., Kouketsu, A., et al.Novel inhibitors of human histone deacetylases: Design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamatesJ. Med. Chem.48(4),1019-1032(2005)
