1-Naphthohydroxamic acid
Cat. No.：YN290240
CAS No. ：6953-61-3
| 产品名称: | 1-Naphthohydroxamic acid |
| CAS No.: | 6953-61-3 |
| Chemical Name: | |
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| 分子量: | 187.19 |
| 分子式: | C₁₁H₉NO₂ |
| SMILES: | O=C(C1=C2C=CC=CC2=CC=C1)NO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-Naphthohydroxamic acid (Compound 2) 是一种有效的，选择性的HDAC8抑制剂，IC50为 14 μM。1-Naphthohydroxamic acid 对HDAC8的选择性高于 I 类 HDAC1 和 II 类 HDAC6 (IC50>100 μM)。1-Naphthohydroxamic acid 不会增加整体组蛋白 H4 的乙酰化，也不会降低总细胞内 HDAC 的活性。1-Naphthohydroxamic acid 可诱导微管蛋白乙酰化。 |
| IC50和靶点: | [{name:"HDAC8:14 μM (IC50)"},{name: "HDAC1:>100 μM (IC50)"},{name: "HDAC6:>100 μM (IC50)"}] |
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