Pyroxamide
Cat. No.：YN290244
CAS No. ：382180-17-8
| 产品名称: | Pyroxamide |
| CAS No.: | 382180-17-8 |
| Chemical Name: | N1-hydroxy-N8-3-pyridinyl-octanediamide |
| Synonyms: | 382180-17-8, NSC-696085, N-Hydroxy-N'-3-pyridinyloctanediamide, n-hydroxy-n'-(pyridin-3-yl)octanediamide, NSC696085, NSC 696085 |
| 分子量: | 265.31 |
| 分子式: | C₁₃H₁₉N₃O₃ |
| SMILES: | O=C(NO)CCCCCCC(NC1=CC=CN=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pyroxamide 是一种有效的组蛋白脱乙酰基酶 1 (HDAC1) 抑制剂，ID50为 100 nM。 Pyroxamide 可以诱导白血病细胞凋亡和细胞周期停滞。 |
| IC50和靶点: | [{name:"HDAC1:100 nM (ID50)"}] |
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| Solvent & Solubility: |
Butler, L.M., Webb, Y., Agus, D.B., et al.Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylaseClin. Cancer Res.7,962-970(2001)
Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al.Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamatesJ. Med. Chem.45(4),753-757(2002)
Kutko, M.C., Glick, R.D., Butler, L.M., et al.Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitroClin. Cancer Res.9,5749-5755(2003)
