M344
Cat. No.：YN290258
| 产品名称: | M344 |
| CAS No.: | 251456-60-7 |
| Chemical Name: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide |
| Synonyms: | D 237; MS 344 |
| 分子量: | 307.39 |
| 分子式: | C₁₆H₂₅N₃O₃ |
| SMILES: | O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | M344 (D 237) 是一种组蛋白去乙酰化酶抑制剂，IC50为 100 nM。 |
| IC50和靶点: | [{name:"HDAC:100 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jung, M., Brosch, G., Kölle, D., et al.Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiationJ. Med. Chem.42(22),4669-4679(1999)
Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al.Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamatesJ. Med. Chem.45(4),753-757(2002)
Heltweg, B., Dequiedt, F., Marshall, B.L., et al.Subtype selective substrates for histone deacetylasesJ. Med. Chem.47(21),5235-5243(2004)
Zhang, Y., Jung, M., Dritschilo, A., et al.Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitorsRadiat. Res.161(6),667-674(2004)
Takai, N., Ueda, T., Nishida, M., et al.M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cellsGynecol. Oncol.101(1),108-113(2006)
