RGFP966
Cat. No.：YN290299
CAS No. ：1357389-11-7
| 产品名称: | RGFP966 |
| CAS No.: | 1357389-11-7 |
| Chemical Name: | (2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide |
| Synonyms: | RGFP 966 |
| 分子量: | 362.40 |
| 分子式: | C₂₁H₁₉FN₄O |
| SMILES: | O=C(NC1=CC=C(F)C=C1N)/C=C/C2=CN(C/C=C/C3=CC=CC=C3)N=C2.[E] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RGFP966 是高选择性的HDAC3抑制剂，IC50为 80 nM，在 15 μM 时对其他 HDAC 无抑制作用。RGFP966 能够透过血脑屏障 (BBB)。 |
| IC50和靶点: | [{name:"HDAC3:80 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Malvaez, M., McQuown, S.C., Rogge, G.A., et al.HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent mannerProc. Natl. Acad. Sci. USA110(7),2647-2652(2013)
Wells, C.E., Bhaskara, S., Stengel, K.R., et al.Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphomaPLoS One8(7),1-13(2013)
