Resminostat hydrochloride
Cat. No.：YN290310
CAS No. ：1187075-34-8
| 产品名称: | Resminostat hydrochloride |
| CAS No.: | 1187075-34-8 |
| Chemical Name: | 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide, monohydrochloride |
| Synonyms: | RAS2410 hydrochloride; 4SC-201 hydrochloride |
| 分子量: | 385.87 |
| 分子式: | C₁₆H₂₀ClN₃O₄S |
| SMILES: | O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Resminostat hydrochloride 是一种有效的HDAC1，HHDAC3和HDAC6抑制剂，IC50值分别为 42.5，50.1，71.8 nM，同时对 HDAC8 有较弱的抑制作用，IC50值为 877 nM。 |
| IC50和靶点: | [{name:"HDAC1:42.5 nM (IC50)"},{name: "HDAC3:50.1 nM (IC50)"},{name: "HDAC6:71.8 nM (IC50)"},{name: "HDAC8:877 nM (IC50)"}] |
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Mandl-Weber, S., Meinel, F.G., Jankowsky, R., et al.The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cellsBr. J. Haematol.149,518-528(2010)
Brunetto, A.T., Ang, J.E., Lal, R., et al.First-in-human, pharmacokinetic and pharmacodynamic phase I study of Resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumorsClin. Cancer Res.19(19),5494-5504(2013)
