Givinostat hydrochloride monohydrate
Cat. No.：YN290321
CAS No. ：732302-99-7
| 产品名称: | Givinostat hydrochloride monohydrate |
| CAS No.: | 732302-99-7 |
| Chemical Name: | N-[4-[(hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate |
| Synonyms: | ITF-2357 hydrochloride monohydrate |
| 分子量: | 475.97 |
| 分子式: | C₂₄H₃₀ClN₃O₅ |
| SMILES: | O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) 是HDAC抑制剂，抑制HDAC1和HDAC3，IC50分别为 198 nM 和 157 nM。 |
| IC50和靶点: | [{name:"hHDAC3:157 nM (IC50)"},{name: "hHDAC1:198 nM (IC50)"},{name: "hHDAC11:292 nM (IC50)"},{name: "hHDAC6:315 nM (IC50)"},{name: "hHDAC2:325 nM (IC50)"},{name: "hHDAC10:340 nM (IC50)"},{name: "hHDAC7:524 nM (IC50)"},{name: "hHDAC5:532 nM (IC50)"},{name: "hHDAC9:541 nM (IC50)"},{name: "hHDAC8:854 nM (IC50)"},{name: "hHDAC4:1059 nM (IC50)"},{name: "HD1-B:7.5 nM (IC50)"},{name: "HD1-A:16 nM (IC50)"},{name: "HD2:10 nM (IC50)"}] |
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Leoni, F., Fossati, G., Lewis, E.C., et al.The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivoMol. Med.11(1-12),1-15(2005)
Guerini, V., Barbui, V., Spinelli, O., et al.The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617FLeukemia22(4),740-747(2008)
