Citarinostat
Cat. No.：YN290380
CAS No. ：1316215-12-9
| 产品名称: | Citarinostat |
| CAS No.: | 1316215-12-9 |
| Chemical Name: | 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide |
| Synonyms: | ACY241 |
| 分子量: | 467.95 |
| 分子式: | C₂₄H₂₆ClN₅O₃ |
| SMILES: | O=C(C1=CN=C(N(C2=CC=CC=C2Cl)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Citarinostat (ACY241) 是第二代有效的，口服活性，高选择性的HDAC6抑制剂，IC50为 2.6 nM (HDAC1，HDAC2，HDAC3 和 HDAC8 的 IC50分别为 35 nM，45 nM，46 nM 和 137 nM)。Citarinostat 具有抗癌作用。 |
| IC50和靶点: | [{name:"HDAC6:2.6 nM (IC50)"},{name: "HDAC1:35 nM (IC50)"},{name: "HDAC2:45 nM (IC50)"},{name: "HDAC3:46 nM (IC50)"},{name: "HDAC8:137 nM (IC50)"},{name: "HDAC7:7300 nM (IC50)"}] |
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Huang, P., Almeciga-Pinto, I., Jarpe, M., et al.Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor modelsOncotarget8(2),2694-2707(2017)
Lorenzo Pisarello, M., Masyuk, T.V., Gradilone, S.A., et al.The combination of an HDAC6 inhibitor and a somatostatin receptor agonist synergistically reduces hepato-renal cystogenesis in an animal model of polycystic liver diseaseAm. J. Pathol.188(4),981-994(2018)
