RG2833
Cat. No.：YN290392
CAS No. ：1215493-56-3
| 产品名称: | RG2833 |
| CAS No.: | 1215493-56-3 |
| Chemical Name: | N-[6-[(2-aminophenyl)amino]-6-oxohexyl]-4-methyl-benzamide |
| Synonyms: | RGFP109 |
| 分子量: | 339.43 |
| 分子式: | C₂₀H₂₅N₃O₂ |
| SMILES: | O=C(NCCCCCC(NC1=CC=CC=C1N)=O)C2=CC=C(C)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RG2833 是一种可透过血脑屏障的HDAC抑制剂，抑制 HDAC1 和 HDAC3 的活性，IC50值分别为 60 nM 和 50 nM，Ki值分别为 32 和 5 nM。 |
| IC50和靶点: | [{name:"HDAC3:50 nM (IC50)"},{name: "HDAC1:60 nM (IC50)"},{name: "HDAC1:32 nM (Ki)"},{name: "HDAC3:5 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rai, M., Soragni, E., Chou, C.J., et al.Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse modelPLoS One5(1),e8825(2010)
