Nexturastat A
Cat. No.：YN290403
CAS No. ：1403783-31-2
| 产品名称: | Nexturastat A |
| CAS No.: | 1403783-31-2 |
| Chemical Name: | 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-benzamide |
| Synonyms: | |
| 分子量: | 341.40 |
| 分子式: | C₁₉H₂₃N₃O₃ |
| SMILES: | O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nexturastat A是HDAC6高度选择性抑制剂，IC50为5 nM，对其它HDAC亚型无抑制性。 |
| IC50和靶点: | [{name:"HDAC6:5.02 nM (IC50)"},{name: "HDAC8:0.954 μM (IC50)"},{name: "HDAC1:3.02 μM (IC50)"},{name: "HDAC7:4.46 μM (IC50)"},{name: "HDAC11:5.14 μM (IC50)"},{name: "HDAC3:6.68 μM (IC50)"},{name: "HDAC9:6.72 μM (IC50)"},{name: "HDAC2:6.92 μM (IC50)"},{name: "HDAC10:7.57 μM (IC50)"},{name: "HDAC4:9.39 μM (IC50)"},{name: "HDAC5:11.7 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bergman, J.A., Woan, K., Perez-Villarroel, P., et al.Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growthJ. Med. Chem.55(22),9891-9899(2012)
