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MC1568

Cat. No.:YN290408

  • CAS No. :852475-26-4

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    • 参考文献
    • 产品名称: MC1568
      CAS No.: 852475-26-4
      Chemical Name: (2E)-3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
      Synonyms:MC1568;(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide;MC-1568;MC1568 (MC-1568, MC 1568);(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide;MC-1568,MC1568;3-[5-(3
      分子量:314.31
      分子式:C₁₇H₁₅FN₂O₃
      SMILES:O=C(NO)/C=C/C1=CC=C(/C=C/C(C2=CC=CC(F)=C2)=O)N1C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: MC1568是组蛋白脱乙酰酶(HDAC II)的抑制剂,可用于癌症研究。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • de Ruijter, A.J., van Gennip, A.H., Caron, H.N., et al.Histone deacetylases (HDACs): Characterization of the classical HDAC familyBiochem J.370(Pt 3),737-749(2003)

      Yang, X.J., and Grégoire, S.Class II histone deacetylases: From sequence to function, regulation, and clinical implicationMol. Cell. Biol.25(8),2873-2884(2005)

      Mai, A., Massa, S., Pezzi, R., et al.Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamidesJ. Med. Chem.48(9),3344-3353(2005)

      Mai, A., Jelicic, K., Rotili, D., et al.Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemiaMol. Pharmacol.72(5),1111-1123(2007)

      Nebbioso, A., Manzo, F., Miceli, M., et al.Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexesEMBO reports10(7),776-782(2009)

      Duong, V., Bret, C., Altucci, L., et al.Specific activity of class II histone deacetylases in human breast cancer cellsMol. Cancer Res.6(12),1908-1919(2008)

      Nebbioso, A., Dell'Aversana, C., Bugge, A., et al.HDACs class II-selective inhibition alters nuclear receptor-dependent differentiationJ. Mol. Endocrinol.45(4),219-228(2010)

      Wang, G., He, J., Zhao, J., et al.Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancerPLoS One7(12),1-10(2012)

      Mannaerts, I., Eysackers, N., Onyema, O.O., et al.Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29PLoS One8(1),1-9(2013)

      Spallotta, F., Tardivo, S., Nanni, S., et al.Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemiaJ. Biol. Chem.288(32),22915-22929(2013)

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