TMP269
Cat. No.：YN290432
CAS No. ：1314890-29-3
| 产品名称: | TMP269 |
| CAS No.: | 1314890-29-3 |
| Chemical Name: | N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-benzamide |
| Synonyms: | TMP 269; TMP-269 |
| 分子量: | 514.52 |
| 分子式: | C₂₅H₂₁F₃N₄O₃S |
| SMILES: | O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TMP269 是一种有效的，选择性的脱乙酰化酶 (HDAC) 抑制剂，能够抑制 HDAC 4/HDAC 5/HDAC 7/HDAC 9，IC50值分别为 157 nM，97 nM，43 nM 和 23 nM。 |
| IC50和靶点: | [{name:"HDAC9:23 nM (IC50)"},{name: "HDAC7:43 nM (IC50)"},{name: "HDAC5:97 nM (IC50)"},{name: "HDAC4:157 nM (IC50)"},{name: "HDAC8:42000 nM (IC50)"},{name: "HDAC6:82000 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
de Ruijter, A.J., van Gennip, A.H., Caron, H.N., et al.Histone deacetylases (HDACs): Characterization of the classical HDAC familyBiochem J.370(Pt 3),737-749(2003)
Yang, X.J., and Grégoire, S.Class II histone deacetylases: From sequence to function, regulation, and clinical implicationMol. Cell. Biol.25(8),2873-2884(2005)
Lobera, M., Madauss, K.P., Pohlhaus, D.T., et al.Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding groupNat. Chem. Biol.9(5),319-325(2013)
