TMP195
Cat. No.：YN290433
CAS No. ：1314891-22-9
| 产品名称: | TMP195 |
| CAS No.: | 1314891-22-9 |
| Chemical Name: | N-[2-methyl-2-(2-phenyl-4-oxazolyl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-benzamide |
| Synonyms: | TFMO 2 |
| 分子量: | 456.42 |
| 分子式: | C₂₃H₁₉F₃N₄O₃ |
| SMILES: | O=C(NCC(C)(C)C1=COC(C2=CC=CC=C2)=N1)C3=CC(C4=NOC(C(F)(F)F)=N4)=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TMP195是选择性的IIa类组蛋白脱乙酰酶 (HDAC) 抑制剂，对HDAC4，HDAC5，HDAC7，HDAC9的Ki值分别为59，60，26，5 nM。 |
| IC50和靶点: | [{name:"HDAC9:9 nM (IC50)"},{name: "HDAC7:46 nM (IC50)"},{name: "HDAC5:106 nM (IC50)"},{name: "HDAC4:111 nM (IC50)"},{name: "HDAC8:11700 nM (IC50)"},{name: "HDAC6:47800 nM (IC50)"}] |
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| Solvent & Solubility: |
Lobera, M., Madauss, K.P., Pohlhaus, D.T., et al.Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding groupNat. Chem. Biol.9(5),319-325(2013)
Guerriero, J.L., Sotayo, A., Ponichtera, H.E., et al.Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophagesNature543(7645),428-432(2017)
