CAY10603
Cat. No.：YN290436
CAS No. ：1045792-66-2
| 产品名称: | CAY10603 |
| CAS No.: | 1045792-66-2 |
| Chemical Name: | N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-carbamic acid, 1,1-dimethylethyl ester |
| Synonyms: | BML-281 |
| 分子量: | 446.50 |
| 分子式: | C₂₂H₃₀N₄O₆ |
| SMILES: | O=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAY10603 (BML-281) 是一种有效的，选择性的HDAC6抑制剂，IC50值为 2 pM；CAY10603 (BML-281) 同时可抑制 HDAC1，HDAC2，HDAC3，HDAC8 和 HDAC10 的活性，IC50值分别为 271，252，0.42，6851，90.7 nM。 |
| IC50和靶点: | [{name:"HDAC6:0.002 nM (IC50)"},{name: "HDAC3:0.42 nM (IC50)"},{name: "HDAC10:90.7 nM (IC50)"},{name: "HDAC2:252 nM (IC50)"},{name: "HDAC1:271 nM (IC50)"},{name: "HDAC8:6851 nM (IC50)"}] |
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| Solvent & Solubility: |
Kozikowski, A.P., Tapadar, S., Luchini, D.N., et al.Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6J. Med. Chem.51,4370-4373(2008)
