SKLB-23bb
Cat. No.：YN290443
| 产品名称: | SKLB-23bb |
| CAS No.: | 1815580-06-3 |
| Chemical Name: | N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-butanamide |
| Synonyms: | |
| 分子量: | 396.44 |
| 分子式: | C₂₁H₂₄N₄O₄ |
| SMILES: | CN(C1=CC(OCCCC(NO)=O)=C(OC)C=C1)C2=NC(C)=NC3=CC=CC=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SKLB-23bb 是一种有效的选择性HDAC6抑制剂，IC50为 17 nM，比抑制HDAC1(IC50= 422 nM) 和HDAC8(IC50=3398 nM) 选择性分别高 25 倍和 200 倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yang, Z., T., W., Wang, F., et al.Discovery of selective histone deacetylase 6 inhibitors using the quinazoline as the cap for the treatment of cancerJ. Med. Chem.59(4),1455-1470(2015)
Wang, F., Zheng, L., Yi, Y., et al.SKLB-23bb, A HDAC6-selective inhibitor, exhibits superior and broad-spectrum antitumor activity via additionally targeting microtubulesMol. Cancer Ther.17(4),763-775(2018)
