LMK-235
Cat. No.：YN290447
CAS No. ：1418033-25-6
| 产品名称: | LMK-235 |
| CAS No.: | 1418033-25-6 |
| Chemical Name: | N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide |
| Synonyms: | LMK235 |
| 分子量: | 294.35 |
| 分子式: | C₁₅H₂₂N₂O₄ |
| SMILES: | O=C(NOCCCCCC(NO)=O)C1=CC(C)=CC(C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LMK-235 是一种有效的，选择性的HDAC4/5抑制剂，可抑制 HDAC5，HDAC4，HDAC6，HDAC1，HDAC2，HDAC11 和 HDAC8 的活性，IC50值分别为 4.22 nM，11.9 nM，55.7 nM，320 nM，881 nM，852 nM 和 1278 nM，可用于癌症研究。 |
| IC50和靶点: | [{name:"HDAC5:4.22 nM (IC50)"},{name: "HDAC4:11.9 nM (IC50)"},{name: "HDAC6:55.7 nM (IC50)"},{name: "HDAC1:320 nM (IC50)"},{name: "HDAC11:852 nM (IC50)"},{name: "HDAC2:881 nM (IC50)"},{name: "HDAC8:1278 nM (IC50)"}] |
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| Solvent & Solubility: |
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Hansen, F.K., Sumanadasa, S.D.M., Stenzel, K., et al.Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stagesEur. J. Med. Chem.82,204-213(2014)
