ACY-738
Cat. No.：YN290451
CAS No. ：1375465-91-0
| 产品名称: | ACY-738 |
| CAS No.: | 1375465-91-0 |
| Chemical Name: | N-hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide |
| Synonyms: | ACY 738 |
| 分子量: | 270.29 |
| 分子式: | C₁₄H₁₄N₄O₂ |
| SMILES: | O=C(NO)C(C=N1)=CN=C1NC2(CC2)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ACY-738 是一种有效的，选择性的，可口服的HDAC6抑制剂，IC50值为 1.7 nM；ACY-738 同时可抑制 HDAC1，HDAC2 和 HDAC3 的活性，IC50值分别为 94，128 和 218 nM。 |
| IC50和靶点: | [{name:"HDAC6:1.7 nM (IC50)"},{name: "HDAC1:94 nM (IC50)"},{name: "HDAC2:128 nM (IC50)"},{name: "HDAC3:218 nM (IC50)"}] |
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Jochems, J., Boulden, J., Lee, B.G., et al.Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailabilityNeuropsychopharmacology39(2),389-400(2014)
Van Helleputte, L., Kater, M., Cook, D.P., et al.Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growthNeurobiol. Dis.111,59-69(2018)
Lorenzo Pisarello, M., Masyuk, T.V., Gradilone, S.A., et al.The combination of an HDAC6 inhibitor and a somatostatin receptor agonist synergistically reduces hepato-renal cystogenesis in an animal model of polycystic liver diseaseAm. J. Pathol.188(4),981-994(2018)
