Bufexamac
Cat. No.：YN290504
| 产品名称: | Bufexamac |
| CAS No.: | 2438-72-4 |
| Chemical Name: | 4-butoxy-N-hydroxy-benzeneacetamide |
| Synonyms: | 丁苯羟酸; Bufexamic acid |
| 分子量: | 223.27 |
| 分子式: | C₁₂H₁₇NO₃ |
| SMILES: | O=C(NO)CC1=CC=C(OCCCC)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bufexamac是 HDAC6 和 HDAC10 的抑制剂，具有抗炎活性。 |
| IC50和靶点: | [{name:"HDAC6:10.7 μM (Kd app)"},{name: "HDAC10:12.3 μM (Kd app)"},{name: "HDAC8:235 μM (Kd app)"},{name: "HDAC3:341 μM (Kd app)"}] |
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Bantscheff, M., Hopf, C., Savitski, M.M., et al.Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexesNat. Biotechnol.29(3),255-265(2011)
Xiao, Q., Dong, N., Yao, X., et al.Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4HSci. Rep.6:25298,(2016)
Summers, J.B., Kim, K.H., Mazdiyasni, H., et al.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationshipsJ. Med. Chem.33(3),992-998(1990)
