Apicidin
Cat. No.：YN290530
| 产品名称: | Apicidin |
| CAS No.: | 183506-66-3 |
| Chemical Name: | cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl] |
| Synonyms: | OSI 2040 |
| 分子量: | 623.78 |
| 分子式: | C₃₄H₄₉N₅O₆ |
| SMILES: | O=C(NC(C(N1[C@]2([H])CCCC1)=O)[C@@H](C)CC)[C@@H](NC([C@@H](NC2=O)CCCCCC(CC)=O)=O)CC3=CN(OC)C4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apicidin (OSI 2040) 是真菌的代谢物， 是一种组蛋白脱乙酰酶(HDAC)抑制剂，具有抗寄生虫活性和广谱的抗增殖活性。 |
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Darkin-Rattray, S.J., Gurnett, A.M., Myers, R.W., et al.Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylaseProc. Natl. Acad. Sci. USA93(23),13143-13147(1996)
Khan, N., Jeffers, M., Kumar, S., et al.Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitorsBiochem. J.409(2),581-589(2008)
Ueda, T., Takai, N., Nishida, M., et al.Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cellsInt. J. Mol. Med.19,301-308(2007)
Luo, B., Chen, J., Zhou, G.-F., et al.Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 miceCNS Neurosci. Ther.(0)0,1-12(2023)
