Suberoyl bis-hydroxamic acid
Cat. No.：YN290552
| 产品名称: | Suberoyl bis-hydroxamic acid |
| CAS No.: | 38937-66-5 |
| Chemical Name: | N1,N8-dihydroxy-octanediamide |
| Synonyms: | Suberohydroxamic acid; SBHA |
| 分子量: | 204.22 |
| 分子式: | C₈H₁₆N₂O₄ |
| SMILES: | O=C(NO)CCCCCCC(NO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) 是竞争性且可透过细胞的HDAC1和HDAC3抑制剂，ID50值分别为 0.25 μM 和 0.30 μM。Suberoyl bis-hydroxamic acid 使肿瘤细胞易于凋亡 (apoptosis) 并促进线粒体凋亡途径。Suberoyl bis-hydroxamic acid 可用于甲状腺髓样癌 (MTC) 的研究。 |
| IC50和靶点: | [{name:"HDAC1:0.25 μM (IC50)"},{name: "HDAC3:0.30 μM (IC50)"}] |
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You, B.R., and Park, W.H.Suberoyl bishydroxamic acid inhibits the growth of A549 lung cancer cells via caspase-dependent apoptosisMol. Cell. Biochem.,(2010)
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