Flavopiridol
Cat. No.：YN250007
CAS No. ：146426-40-6
| 产品名称: | Flavopiridol |
| CAS No.: | 146426-40-6 |
| Chemical Name: | 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one |
| Synonyms: | 夫拉平度; HMR-1275; Alvocidib; L86-8275 |
| 分子量: | 401.84 |
| 分子式: | C₂₁H₂₀ClNO₅ |
| SMILES: | O=C1C2=C(C=C(C([C@]3([H])[C@H](O)CN(C)CC3)=C2OC(C4=CC=CC=C4Cl)=C1)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Flavopiridol (Alvocidib) 是一种竞争型的CDK广谱抑制剂， 抑制 CDK1，CDK2，CDK4的IC50分别为30，170，100 nM。 |
| IC50和靶点: | [{name:"CDK1/Cyc B1:30 nM (IC50)"},{name: "CDK2/Cyc E:170 nM (IC50)"},{name: "CDK4/Cyc D1:100 nM (IC50)"},{name: "MAP:19000 nM (IC50)"},{name: "PKC:14000 nM (IC50)"},{name: "EGFR:22000 nM (IC50)"}] |
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Senderowicz, A.M., and Sausville, E.A.Preclinical and clinical development of cyclin-dependent kinase modulatorsJ. Natl. Cancer Inst.92(5),376-387(2000)
Chao, S.H., Fujinaga, K., Marion, J.E., et al.Flavopiridol inhibits P-TEFb and blocks HIV-1 replicationJ. Biol. Chem.275(37),28345-28348(2000)
Sekine, C., Sugihara, T., Miyake, S., et al.Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitorsJ. Immunol.180(3),1954-1961(2008)
