BRD-6929
Cat. No.：YN250042
CAS No. ：849234-64-6
| 产品名称: | BRD-6929 |
| CAS No.: | 849234-64-6 |
| Chemical Name: | 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-benzamide |
| Synonyms: | BRD 6929;Compound-60 |
| 分子量: | 351.42 |
| 分子式: | C₁₉H₁₇N₃O₂S |
| SMILES: | O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD-6929 (Cpd-60) 是HDAC1和HDAC2的脑渗透性选择性抑制剂 (IC50= 1 和 8 nM)，源于专利文献 US2018360927。BRD-6929 (Cpd-60) 对 HDAC1 和 HDAC2 有高亲和力 (Ki= 0.2 和 1.5 nM)。BRD-6929 (TPB) 增强了 gnidimacrin (PKC 激动剂) 对潜伏 HIV 的功效。 |
| IC50和靶点: | [{name:"HDAC1:1 nM (IC50)"},{name: "HDAC2:8 nM (IC50)"},{name: "HDAC3:458 nM (IC50)'}, 'HIV-1'] |
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| Solvent & Solubility: |
Moradei, O.M., Mallais, T.C., Frechette, S., et al.Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivityJ. Med. Chem.50(23),5543-5546(2007)
