Panobinostat
Cat. No.：YN250085
CAS No. ：404950-80-7
| 产品名称: | Panobinostat |
| CAS No.: | 404950-80-7 |
| Chemical Name: | (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Synonyms: | 帕比司他; LBH589; NVP-LBH589 |
| 分子量: | 349.43 |
| 分子式: | C₂₁H₂₃N₃O₂ |
| SMILES: | O=C(/C=C/C1=CC=C(CNCCC2=C(NC3=C2C=CC=C3)C)C=C1)NO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Panobinostat (LBH589; NVP-LBH589) 是一种有效的口服非选择性HDAC抑制剂，具有抗肿瘤活性。Panobinostat 可诱导HIV-1 virus的产生，即使在较低的浓度范围 8-31 nM，也可刺激 HIV-1 在潜伏感染细胞中的表达。Panobinostat 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。Panobinostat 可用于难治性或复发性多发性骨髓瘤的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wang, H., Yu, N., Chen, D., et al.Discovery of (2E)-3-{2-butyl-1-[2-diethylamino)ethyl]-1H-benzamidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profileJ. Med. Chem.54(13),4694-4720(2011)
Crisanti, M.C., Wallace, A.F., Kapoor, V., et al.The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancerMol. Cancer Ther.8(8),2221-2231(2009)
