Delavirdine mesylate
Cat. No.：YN250119
CAS No. ：147221-93-0
| 产品名称: | Delavirdine mesylate |
| CAS No.: | 147221-93-0 |
| Chemical Name: | N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-methanesulfonamide, monomethanesulfonate |
| Synonyms: | U 90152 mesylate; BHAP-U 90152 mesylate |
| 分子量: | 552.67 |
| 分子式: | C₂₃H₃₂N₆O₆S₂ |
| SMILES: | O=S(NC1=CC=C(NC(C(N2CCN(C3=C(NC(C)C)C=CC=N3)CC2)=O)=C4)C4=C1)(C)=O.O=S(O)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Delavirdine (U 90152; BHAP-U 90152) mesylate 是一种有效的口服活性非核苷逆转录酶抑制剂 (NNRTI)。Delavirdine mesylate 选择性地抑制 HIV-1 逆转录酶 (HIV-1 RT) (IC50=0.26 μM)，选择性超过 DNA 聚合酶 α (IC50=440 μM) 和 DNA聚合酶 δ (IC50>550 μM)。Delavirdine mesylate 是 HIV-1 病毒复制的抑制剂，可以用于艾滋病的相关研究。 |
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Dueweke, T.J., Poppe, S.M., Romero, D.L., et al.U-90152, a potent inhibitor of human immunodeficiency virus type 1 replicationAntimicrob. Agents Chemother.37(5),1127-1131(1993)
Costa, S., Machado, M., Cavadas, C., et al.Antileishmanial activity of antiretroviral drugs combined with miltefosineParasitol Res.115(10),3881-3887(2016)
