Efavirenz
Cat. No.：YN250120
| 产品名称: | Efavirenz |
| CAS No.: | 154598-52-4 |
| Chemical Name: | (4S)-6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one |
| Synonyms: | 依法韦仑; DMP 266; EFV; L-743726 |
| 分子量: | 315.68 |
| 分子式: | C₁₄H₉ClF₃NO₂ |
| SMILES: | ClC1=CC=C(NC(O[C@]2(C#CC3CC3)C(F)(F)F)=O)C2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Efavirenz 是一种有效的野生型HIV-1 RT抑制剂，Ki为 2.93 nM，抑制 HIV-1 复制，IC95为 1.5 nM。 |
| IC50和靶点: | |
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Young, S.D., Britcher, S.F., Tran, L.O., et al.L-743,726 (DMP-266): A novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptaseAntimicrob. Agents Chemother.39(12),2602-2605(1995)
Grobler, J.A., Dornadula, G., Rice, M.R., et al.HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitroJ. Biol. Chem.282(11),8005-8010(2007)
Goffinet, C., Allespach, I., and Keppler, O.T.HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcriptionProc. Natl. Acad. Sci. USA104(3),1015-1020(2007)
Sheran, M.The nonnucleoside reverse transcriptase inhibitors efavirenz and nevirapine in the treatment of HIVHIV Clin.Trials6(3),158-168(2005)
Rakhmanina, N.Y., and van den Anker, J.N.Efavirenz in the therapy of HIV infectionExpert Opin. Drug Metab. Toxicol.6(1),95-103(2010)
