ABBV-744
Cat. No.：YN250208
CAS No. ：2138861-99-9
| 产品名称: | ABBV-744 |
| CAS No.: | 2138861-99-9 |
| Chemical Name: | N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide |
| Synonyms: | ABBV744 |
| 分子量: | 491.55 |
| 分子式: | C₂₈H₃₀FN₃O₄ |
| SMILES: | CC(O)(C)C1=CC(C(C2=C3NC(C(NCC)=O)=C2)=CN(C)C3=O)=C(OC4=C(C)C=C(F)C=C4C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABBV-744 是一种结合域 II 选择性的BET bromodomain抑制剂，可用于炎症，癌症，艾滋病等的研究。 |
| IC50和靶点: | [{name:"BRD2 (BD2):8 nM (IC50)"},{name: "BRD3 (BD2):13 nM (IC50)"},{name: "BRDT (BD2):18 nM (IC50)"},{name: "BRD4 (BD2):4 nM (IC50)"},{name: "BRD4 (BD2):3 nM (Kd)"}] |
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Sheppard, G.S., Wang, L., Fidanze, S.D., et al.Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second BromodomainJ. Med. Chem.63(10),5585-5623(2020)
Faivre, E., McDaniel, K.F., Albert, D.H., et al.Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancerNature578(7794),306-310(2020)
