BTZ043
Cat. No.：YN250497
CAS No. ：1161233-85-7
| 产品名称: | BTZ043 |
| CAS No.: | 1161233-85-7 |
| Chemical Name: | 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
| Synonyms: | BTZ043;2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one;BTZ-043;2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one;BTZ 043;G55ZH52P57;MMV676603; |
| 分子量: | 431.39 |
| 分子式: | C₁₇H₁₆F₃N₃O₅S |
| SMILES: | O=C1N=C(N(CC2)CCC32OC[C@H](C)O3)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BTZ043 是 DprE1 的抑制剂，它对结核分枝杆菌 H37Rv (M. tuberculosis H37Rv) 和耻垢分枝杆菌 (Mycobacterium smegmatis) 的 MIC 值分别为 2.3 nM 和 9.2 nM。 |
| IC50和靶点: | |
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Makarov, V., Manina, G., Mikusova, K., et al.Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesisScience324(5928),801-804(2009)
Vera-Cabrera, L., Campos-Rivera, M.P., Gonzalez-Martinez, N.A., et al.In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensisAntimicrob. Agents Chemother.56(7),3984-3985(2012)
