BMS-378806
Cat. No.：YN250580
CAS No. ：357263-13-9
| 产品名称: | BMS-378806 |
| CAS No.: | 357263-13-9 |
| Chemical Name: | 1-[(2R)-4-benzoyl-2-methyl-1-piperazinyl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2-ethanedione |
| Synonyms: | BMS-806 |
| 分子量: | 406.43 |
| 分子式: | C₂₂H₂₂N₄O₄ |
| SMILES: | COC1=C2C(NC=C2C(C(N3CCN(C[C@H]3C)C(C4=CC=CC=C4)=O)=O)=O)=NC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-378806 是一种有效的HIV-1抑制剂，干扰 CD4-gp120 相互作用。BMS-378806选择性抑制 HIV-1 gp120 结合到 CD4 受体，EC50为 0.85-26.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Guo, Q., Ho, H.T., Dicker, I., et al.Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactionsJ. Virol.77(19),10528-10536(2003)
Madani, N., Perdigoto, A.L., Srinivasan, K., et al.Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155J. Virol.78(7),3742-3752(2004)
Si, Z., Madani, N., Cox, J.M., et al.Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteinsProc. Natl. Acad. Sci. USA101(14),5036-5041(2004)
Lin, P.F., Blair, W., Wang, T., et al.A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor bindingProc. Natl. Acad. Sci. USA100(19),11013-11018(2003)
