Apricitabine
Cat. No.：YN250613
| 产品名称: | Apricitabine |
| CAS No.: | 160707-69-7 |
| Chemical Name: | 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone |
| Synonyms: | SPD754; AVX754 |
| 分子量: | 229.26 |
| 分子式: | C₈H₁₁N₃O₃S |
| SMILES: | O=C1N=C(N)C=CN1[C@@H]2S[C@H](CO)OC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apricitabine (SPD754; AVX754) 是 2'-脱氧-3'-oxa-4'-硫代胞苷 (dOTC) 的 (-) 对映体，是一种高度选择性和口服活性的HIV-1 RT逆转录酶抑制剂 (Ki=0.08 μM) 以及抑制 DNA 聚合酶 α, β 和 γ，Ki值分别为 300 μM，12 μM 和 112.25 μM。Apricitabine (SPD754; AVX754) 表现出的好的抗逆转录病毒疗效，良好的耐受性，并且在初次抗逆转录病毒的 HIV 感染中耐药选择性的倾向较低。 |
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Cox, S., and Southby, J.Apricitabine--a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugsExpert Opin. Investig. Drugs18(2),199-209(2009)
Mansour, T.S., Jin, H., Wang, W., et al.Structure-activity relationships among a new class of antiviral heterosubstituted 2′,3′-dideoxynucleoside analoguesNucleos. Nucleot.14(3-5),627-635(1995)
