Doravirine
Cat. No.：YN250682
CAS No. ：1338225-97-0
| 产品名称: | Doravirine |
| CAS No.: | 1338225-97-0 |
| Chemical Name: | 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-benzonitrile |
| Synonyms: | 多拉维林; MK-1439 |
| 分子量: | 425.75 |
| 分子式: | C₁₇H₁₁ClF₃N₅O₃ |
| SMILES: | N#CC1=CC(OC2=C(C(F)(F)F)C=CN(CC(N3C)=NNC3=O)C2=O)=CC(Cl)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Doravirine (MK-1439) 是一种高度特异性的HIV-1非核苷逆转录酶抑制剂，对野生型以及K103N和Y181C逆转录酶突变体的IC50值分别为 4.5 nM，5.5 nM 和 6.1 nM。 |
| IC50和靶点: | |
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Côté, B., Burch, J.D., Asante-Appiah, E., et al.Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV virusesBioorg. Med. Chem. Lett.24(3),917-922(2014)
