BRD3308
Cat. No.：YN250811
CAS No. ：1550053-02-5
| 产品名称: | BRD3308 |
| CAS No.: | 1550053-02-5 |
| Chemical Name: | 4-(acetylamino)-N-(2-amino-4-fluorophenyl)-benzamide |
| Synonyms: | BRD 3308,BRD-3308,BRD3308 |
| 分子量: | 287.29 |
| 分子式: | C₁₅H₁₄FN₃O₂ |
| SMILES: | O=C(C)NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD3308 是一种高选择性的HDAC3抑制剂，IC50为 54 nM。BRD3308 对HDAC3的选择性是 HDAC1 (IC50为 1.26 μM) 或 HDAC2 (IC50为 1.34 μM) 的 23 倍。BRD3308 抑制由炎性细胞因子或糖脂毒性应激诱导的胰腺 β 细胞凋亡，并增加功能性胰岛素释放。BRD3308 还可激活HIV-1转录并破坏HIV-1潜伏期。 |
| IC50和靶点: | [{name:"HDAC3:54 nM (IC50)"},{name: "HDAC3:29 nM (Ki)"},{name: "HDAC1:1260 nM (IC50)"},{name: "HDAC1:5100 nM (Ki)"},{name: "HDAC2:1340 nM (IC50)"},{name: "HDAC2:6300 nM (Ki)'}, 'HIV-1'] |
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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell ProtectionACS Chem. Biol.11(2),363-374(2016)
Lundh, M., Galbo, T., Poulsen, S.S., et al.Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic ratsDiabetes Obes. Metab.17(7),703-707(2015)
