Didanosine
Cat. No.：YN250968
| 产品名称: | Didanosine |
| CAS No.: | 69655-05-6 |
| Chemical Name: | 2',3'-dideoxy-inosine |
| Synonyms: | 2',3'-Dideoxyinosine; ddI |
| 分子量: | 236.23 |
| 分子式: | C₁₀H₁₂N₄O₃ |
| SMILES: | OC[C@@H]1CC[C@H](N2C=NC3=C2N=CN=C3O)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Didanosine(Videx)是逆转录酶抑制剂，IC50为490nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Perry, C.M., and Noble, S.Didanosine: An updated review of its use in HIV infectionDrugs58(6),1099-1135(1999)
Anantharaman, V., and Moen, L.K.Effects of nucleoside analogs on native and site-directed mutants of HTLV type 1 reverse transcriptaseBioorg. Chem.28(5),293-305(2000)
Eron, J.J., Chow, Y.-K., Caliendo, A.M., et al.pol Mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivoAntimicrob. Agents Chemother.37(7),1480-1487(1993)
Benbrik, E., Chariot, P., Bonavaud, S., et al.Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cellsJ. Neurol. Sci.149(1),19-25(1997)
Kaneshima, H., Shih, C.C., Namikawa, R., et al.Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouseProc. Natl. Acad. Sci. USA88(10),4523-4527(1991)
