Cepharanthine
Cat. No.：YN251734
| 产品名称: | Cepharanthine |
| CAS No.: | 481-49-2 |
| Chemical Name: | 2,3,13,14,14aS,15,26,26aR-octahydro-22,30-dimethoxy-1,14-dimethyl-1H-4,6:16,19-dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2’,3’:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline |
| Synonyms: | 千金藤碱 |
| 分子量: | 606.71 |
| 分子式: | C₃₇H₃₈N₂O₆ |
| SMILES: | [H][C@]12N(C)CCC(C1=C3)=CC(OC)=C3OC4=C5C(OCO5)=CC6=C4[C@](N(C)CC6)([H])CC(C=C7)=CC=C7OC8=C(OC)C=CC(C2)=C8 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cepharanthine 是从Stephania cepharanthaHayata 中提取的生物碱，具有抗炎、抗氧化作用。Cepharanthine 能减轻肢体缺血再灌注 (I/R) 引起的肌肉和肾脏损伤。Cepharanthine 能诱导乳腺癌细胞发生自噬、凋亡和细胞周期阻滞。Cepharanthine 通过降低细胞膜的流动性来抑制 HIV-1 入侵。 |
| IC50和靶点: | [{name:"CYP3A4:16.29 μM (IC50)"},{name: "CYP2E1:25.62 μM (IC50)"},{name: "CYP2C9:24.57 μM (IC50)"}] |
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Matsuda, K., Hattori, S., Komizu, Y., et al.Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidityBioorg. Med. Chem. Lett.24(9),2115-2117(2014)
Desgrouas, C., Chapus, C., Desplans, J., et al.In vitro antiplasmodial activity of cepharanthineMalar. J.13:327,(2014)
Rogosnitzky, M., and Danks, R.Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditionsPharmacol. Rep.63(2),337-347(2011)
Huang, H., Hu, G., Wang, C., et al.Cepharanthine, an alkaloid from Stephania cepharantha Hayata, inhibits the inflammatory response in the RAW264.7 cell and mouse modelsInflammation37(1),235-246(2014)
Chen, Z., Huang, C., Yang, Y.l., et al.Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cellsActa Pharmacol. Sin.33(1),101-108(2012)
