3-Deazaadenosine
Cat. No.：YN251922
| 产品名称: | 3-Deazaadenosine |
| CAS No.: | 6736-58-9 |
| Chemical Name: | 1-β-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine |
| Synonyms: | 3-脱氮腺苷 |
| 分子量: | 266.25 |
| 分子式: | C₁₁H₁₄N₄O₄ |
| SMILES: | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=C3)N=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Deazaadenosine 是一种 S-腺苷高半胱氨酸水解酶 (S-adenosylhomocysteine hydrolase) 抑制剂，Ki值为 3.9 µM；3-Deazaadenosine 具有抗炎、抗增殖、抗HIV等活性。 |
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Chiang, P.K.Biological effects of inhibitors of S-adenosylhomocysteine hydrolasePharmacol. Ther.77(2),115-134(1998)
Gordon, R.K., Ginalski, K., Rudnicki, W.R., et al.Anti-HIV-1 activity of 3-deaza-adenosine analogs: Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congenersEur. J. Biochem.270(17),3507-3517(2003)
Jurgensen, C.H., Huber, B.E., Zimmerman, T.P., et al.3-Deazaadenosine inhibits leukocyte adhesion and ICAM1 biosynthesis in tumor necrosis factor-stimulated human endothelial cellsJ. Immunol.144(2),653-661(1990)
Jeong, S.Y., Ahn, S.G., Lee, J.H., et al.3-Deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-κB regulationJ. Biol. Chem.274(27),18981-18988(1999)
Long, M.C., Allan, P.W., Luo, M.Z., et al.Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growthJ. Antimicrob. Chemother.59(1),118-121(2007)
Huggins, J., Zhang, Z.X., and Bray, M.Antiretroviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse modelJ. Infect. Dis.179(Suppl. 1),S240-S247(1999)
