Lopinavir
Cat. No.：YN372211
| 产品名称: | Lopinavir |
| CAS No.: | 192725-17-0 |
| Chemical Name: | N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-αS-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide |
| Synonyms: | 洛匹那韦; ABT-378 |
| 分子量: | 628.80 |
| 分子式: | C₃₇H₄₈N₄O₅ |
| SMILES: | CC1=C(OCC(N[C@@H](CC2=CC=CC=C2)[C@@H](O)C[C@H](CC3=CC=CC=C3)NC([C@H](C(C)C)N4C(NCCC4)=O)=O)=O)C(C)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lopinavir是高亲和性HIV蛋白酶抑制剂，Ki为1.3 pM。 |
| IC50和靶点: | |
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Sham, H.L., Kempf, D.J., Molla, A., et al.ABT-378, a highly potent inhibitor of the human immunodeficiency virus proteaseAntimicrob. Agents Chemother.42(12),3218-3224(1998)
Choy, K.-T., Wong, A.-Y., Kaewpreedee, P., et al.Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitroAntiviral Res.178,104786(2020)
Chan, J.-F., Yao, Y., Yeung, M.-L., et al.Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmosetJ. Infect. Dis.212(12),1904-1913(2015)
