Tipranavir
Cat. No.：YN372261
| 产品名称: | Tipranavir |
| CAS No.: | 174484-41-4 |
| Chemical Name: | N-[3-[(1R)-1-[(6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide |
| Synonyms: | PNU-140690 |
| 分子量: | 602.66 |
| 分子式: | C₃₁H₃₃F₃N₂O₅S |
| SMILES: | O=C1C([C@H](CC)C2=CC=CC(NS(C3=CC=C(C(F)(F)F)C=N3)(=O)=O)=C2)=C(O)C[C@](CCC4=CC=CC=C4)(CCC)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tipranavir (PNU-140690) 有效抑制 HIV-1 蛋白酶 酶活性和二聚化，对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性，IC50为 66-410 nM。 |
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Turner, S.R., Strohbach, J.W., Tommasi, R.A., et al.Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide classJ. Med. Chem.41(18),3467-3476(1998)
Thaisrivongs, S., and Strohbach, J.W.Structure-based discovery of Tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitorBiopoly.51(1),51-58(1999)
Llibre, J.M., Schapiro, J.M., and Clotet, B.Clinical implications of genotypic resistance to the newer antiretroviral drugs in HIV-1-infected patients with virological failureClin. Infect. Dis.50(6),872-881(2010)
