Darunavir
Cat. No.：YN372425
| 产品名称: | Darunavir |
| CAS No.: | 206361-99-1 |
| Chemical Name: | N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester |
| Synonyms: | 达芦那韦; TMC114; UIC-94017 |
| 分子量: | 547.66 |
| 分子式: | C₂₇H₃₇N₃O₇S |
| SMILES: | O=C(O[C@@H]1[C@@]2([H])[C@@](OCC2)([H])OC1)N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C(N)C=C4)=O)CC(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Darunavir (TMC114) 是一个口服有效的、二代HIV蛋白酶抑制剂，对突变型病毒和野生型病毒有类似的抗病毒活性。Darunavir (TMC114) 对实验室 HIV-1 毒株和临床分离株 (IC50= 0.003；IC90= 0.009 μM) 有效。细胞毒性小。 |
| IC50和靶点: | |
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Koh, Y., Nakata, H., Maeda, K., et al.Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitroAntimicrob. Agents Chemother.47(10),3123-3129(2003)
Titanji, B.K., Aasa-Chapman, M., Pillay, D., et al.Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cellsRetrovirology10,161(2013)
