Ritonavir
Cat. No.：YN372698
CAS No. ：155213-67-5
| 产品名称: | Ritonavir |
| CAS No.: | 155213-67-5 |
| Chemical Name: | (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester |
| Synonyms: | 利托那韦; ABT 538; RTV |
| 分子量: | 720.94 |
| 分子式: | C₃₇H₄₈N₆O₅S₂ |
| SMILES: | O=C(N[C@@H](CC1=CC=CC=C1)[C@H](C[C@H](CC2=CC=CC=C2)NC([C@H](C(C)C)NC(N(CC3=CSC(C(C)C)=N3)C)=O)=O)O)OCC4=CN=CS4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的HIV 蛋白酶的抑制剂。 |
| IC50和靶点: | |
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Kempf, D.J., Shan, H.L., Marsh, K.C., et al.Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacyJ. Med. Chem.41(4),602-617(1998)
Koh, Y., Nakata, H., Maeda, K., et al.Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitroAntimicrob. Agents Chemother.47(10),3123-3129(2003)
Kumar, G.N., Dykstra, J., Roberts, E.M., et al.Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interactionDrug Metab. Dispos.27(8),902-908(1999)
Kempf, D.J., Marsh, K.C., Kumar, G., et al.Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavirAntimicrob. Agents Chemother.41(3),654-660(1997)
