Escin IA
Cat. No.：YN373132
| 产品名称: | Escin IA |
| CAS No.: | 123748-68-5 |
| Chemical Name: | (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranosiduronic acid |
| Synonyms: | 七叶皂苷A |
| 分子量: | 1131.26 |
| 分子式: | C₅₅H₈₆O₂₄ |
| SMILES: | OC[C@]1([C@H]2OC(C)=O)[C@](CC(C)(C)[C@H]2OC(/C(C)=C/C)=O)([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@@](O[C@H](C(O)=O)[C@@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@ |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Escin IA 是从马蹄中七叶树分离出的一种三萜皂苷，抑制HIV-1蛋白酶，IC50值为 35 μM，Escin IA 具有抗三阴乳腺癌转移活性，其作用机制包括下调 LOXL 表达抑制上皮间充质转化过程。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Yang, X.-W., Zhao, J., Cui, Y.-X., et al.Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensisJ. Nat. Prod.62(11),1510-1513(1999)
Wang, Y., Xu, X., Zhao, P., et al.Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expressionOncotarget7(17),23684-23699(2016)
Matsuda, H., Li, Y., Murakami, T., et al.Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animalsBiol. Pharm. Bull.20(10),1092-1095(1997)
Matsuda, H., Murakami, T., Li, Y., et al.Mode of action of escins Ia and IIa and E,Z-senegin II on glucose absorption in gastrointestinal tractBioorg. Med. Chem.6(7),1019-1023(1998)
