Cytochalasin A
Cat. No.：YN373368
| 产品名称: | Cytochalasin A |
| CAS No.: | 14110-64-6 |
| Chemical Name: | (3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione |
| Synonyms: | 细胞松弛素A |
| 分子量: | 477.59 |
| 分子式: | C₂₉H₃₅NO₅ |
| SMILES: | C[C@@H]([C@@]([C@@]12[C@](/C=C/C[C@H](C)CCCC(/C=C/C(O1)=O)=O)([H])[C@@H]3O)([H])[C@@H](NC2=O)CC4=CC=CC=C4)C3=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytochalasin A 是细胞可渗透的真菌毒素，是细胞松弛素 B 的氧化衍生物。Cytochalasin A 是HIV-1蛋白酶的抑制剂 (IC50=3 μM)，抑制肌动蛋白聚合，并通过与巯基反应干扰微管组装。具有抗生素和灭真菌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Brenner, S.L., and Korn, E.D.The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerizationJ. Biol. Chem.255(3),841-844(1980)
Lin, D.C., Tobin, K.D., Grumet, M., et al.Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongationJ. Cell Biol.84(2),455-460(1980)
Ostlund, R.E., Jr., Leung, J.T., and Hajek, S.V.Regulation of microtubule assembly in cultured fibroblastsJ. Cell Biol.85(2),386-391(1980)
Pinder, J.C., and Gratzer, W.B.Structural and dynamic states of actin in the erythrocyteJ. Cell Biol.96(3),768-775(1983)
Flaumenhaft, R., Dilks, J.R., Rozenvayn, N., et al.The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretionBlood105(10),3879-3887(2005)
Taheri-Talesh, N., Horio, T., Araujo-Bazán, L., et al.The tip growth apparatus of Aspergillus nidulansMol. Biol. Cell19(4),1439-1449(2008)
dos Santos, T., Varela, J., Lynch, I., et al.Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell linesPLoS One6(9),1-10(2011)
Nightingale, T.D., White, I.J., Doyle, E.L., et al.Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosisJ. Cell Biol.194(4),613-629(2011)
Lingham, R.B., Hsu, A., Silverman, K.C., et al.L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. III. Biological activityJ. Antibiot. (Tokyo)45(5),686-691(1992)
Kletzien, R.F., Perdue, J.F., and Springer, A.Cytochalasin A and B. Inhibition of sugar uptake in cultured cellsJ. Biol. Chem.247(9),2964-2966(1972)
Griffin, J.F., Rampal, A.L., and Jung, C.Y.Inhibition of glucose transport in human erythrocytes by cytochalasins: A model based on diffraction studiesProc. Natl. Acad. Sci. USA79(12),3759-3763(1982)
Araki, T., and Williams, J.G.Perturbations of the actin cytoskeleton activate a Dictyostelium STAT signalling pathwayEur. J. Cell Biol.91(5),420-425(2012)
