KNK437
Cat. No.：YN370010
CAS No. ：218924-25-5
| 产品名称: | KNK437 |
| CAS No.: | 218924-25-5 |
| Chemical Name: | 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde |
| Synonyms: | Heat Shock Protein Inhibitor I |
| 分子量: | 245.23 |
| 分子式: | C₁₃H₁₁NO₄ |
| SMILES: | O=CN1C(/C(CC1)=C/C2=CC=C(OCO3)C3=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KNK437 是HSP抑制剂，能够抑制 HSP105，HSP70 和 HSP40 的活化。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yokota, S., Kitahara, M., and Nagata, K.Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cellsCancer Res.60(11),2942-2948(2000)
Koishi, M., Yokota, S., Mae, T., et al.The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivoClin. Cancer Res.7(1),215-219(2001)
