KRIBB11
Cat. No.：YN370107
CAS No. ：342639-96-7
| 产品名称: | KRIBB11 |
| CAS No.: | 342639-96-7 |
| Chemical Name: | N2-1H-indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine |
| Synonyms: | KRIBB11;KRIBB-11;N2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;BCP19297;s8402;BDBM50114871;AK685532;A16347;N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine;N-(1H-Indazole-5-y |
| 分子量: | 284.27 |
| 分子式: | C₁₃H₁₂N₆O₂ |
| SMILES: | CNC1=CC=C([N+]([O-])=O)C(NC2=CC3=C(NN=C3)C=C2)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KRIBB11 是HSF1的抑制剂，IC50值为 1.2 μM。 |
| IC50和靶点: | [{name:"HSF1:1.2 μM (IC50)"}] |
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Yoon, Y.J., Kim, J.A., Shin, K.D., et al.KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoterJ. Biol. Chem.286(3),1737-1747(2011)
Tsai, T.T., Chen, C.L., Tsai, C.C., et al.Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivoAntiviral Res.145,44-53(2017)
