Tanespimycin
Cat. No.：YN370232
CAS No. ：75747-14-7
| 产品名称: | Tanespimycin |
| CAS No.: | 75747-14-7 |
| Chemical Name: | 17-demethoxy-17-(2-propenylamino)-geldanamycin |
| Synonyms: | 坦螺旋霉素; 17-AAG; NSC 330507; CP 127374 |
| 分子量: | 585.69 |
| 分子式: | C₃₁H₄₃N₃O₈ |
| SMILES: | O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tanespimycin (17-AAG) 是有效的HSP90抑制剂，IC50为 5 nM，对肿瘤细胞 HSP90 的亲和性比正常细胞高 100 倍。Tanespimycin 消耗细胞内 STK38/NDR1，并降低 STK38 激酶活性。Tanespimycin 还下调stk38基因表达。 |
| IC50和靶点: | [{name:"HSP90:5 nM (IC50)'}, 'Autophagy', 'Mitophagy'] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
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Weber, H., Valbuena, J.R., Barbhuiya, M.A., et al.Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancerOncotarget8(16),26169-26184(2017)
